Journal of Theoretical Medicine
Volume 4 (2002), Issue 3, Pages 191-196

Application of a New Processing Method to Post-LDL-apheresis Data

1Medical and Surgical Paediatric Sciences Complex Unit, University of Bologna, Italy
2Clinical Medicine and Applied Biotechnology Department “D. Campanacci”, Atherosclerosis centre “G. Descovich”, University of Bologna, Orsola-Malpighi Hospital, Via Massarenti 9, 40138 Bologna, Italy
3Clinical Medicine and Applied Biotechnology Department “D. Campanacci”, University of Bologna, Italy

Received 18 October 2001; Accepted 29 July 2002

Copyright © 2002 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Our aim was to elaborate a method to optimise treatment intervals for the individual low-density lipoprotein (LDL)-apheresis treated patients. After each treatment, plasma LDL concentrations show a time-related increase with a decreasing speed until a maximum level.We searched to interpret the post-LDL-apheresis experimental data trend as the physical process that produces the observed curve, so that the fitting presupposed theoretical function is a direct consequence of the physic process, because to establish the better time. Applying the proposed fitting method to a succession of 15 samples obtained from the mean of six plasmapheresis executed on five different subjects, small estimate standard error (5 mg/dl) and relative error (1.7%) with a dispersion evidently related to the experimental error were observed. Obviously, applying the same method to a single case, the dispersion is more marked (relative error <5%), with a SE of 10-13 mg/dl, even though the aspect of a casual phenomenon is conserved. Our physical interpretation appears to be a practical model to predict the LDL-rebound kinetic of the single patient.